| Scry Ambush | 4th-level | divination | bard, cleric, druid, ranger, sorcerer, warlock, wizard | Deep Magic 5e |
| Scrying | 5th-level | divination | cleric, druid, bard, warlock, wizard | 5e Core Rules |
| Scrying | 5th-level | divination | bard, cleric, druid, warlock, wizard | Level Up Advanced 5e |
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| Seal of Sanctuary | 7th-level | abjuration | cleric, warlock, wizard | Deep Magic 5e |
| Seal Red Portal | 6th-level | abjuration | wizard | Kobold Press Compilation |
| Searing Equation | 1st-level | enchantment | artificer, warlock, wizard | Level Up Advanced 5e |
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| Secret Blind | 3rd-level | evocation | sorceror, warlock, wizard | Tome of Heroes |
| Secret Chest | 4th-level | conjuration | wizard | 5e Core Rules |
| Secret Chest | 4th-level | conjuration | wizard | Level Up Advanced 5e |
| See Beyond | 5th-level | divination | bard, druid, ranger, wizard | Deep Magic 5e |
| See Invisibility | 2nd-level | divination | bard, sorcerer, wizard | 5e Core Rules |
| See Invisibility | 2nd-level | divination | artificer, bard, sorcerer, wizard | Level Up Advanced 5e |
| Seed Bomb | 2nd-level | conjuration | druid, wizard | Level Up Advanced 5e |
| Seed of Destruction | 8th-level | enchantment | bard, cleric, druid, paladin, ranger, sorcerer, warlock, wizard | Deep Magic 5e |
| Seeming | 5th-level | illusion | bard, sorcerer, warlock, wizard | 5e Core Rules |
| Seeming | 5th-level | illusion | bard, sorcerer, wizard | Level Up Advanced 5e |
| Seeping Death | 3rd-level | necromancy | cleric, druid, warlock, wizard | Deep Magic 5e |
| Seer’s Reaction | 1st-level | divination | bard, cleric, druid, ranger, sorcerer, wizard | Deep Magic 5e |
| Selfish Wish | 9th-level | conjuration | wizard | Kobold Press Compilation |
| Semblance of Dread | Cantrip | illusion | bard, cleric, druid, paladin, ranger, sorcerer, warlock, wizard | Deep Magic 5e |
| Sending | 3rd-level | evocation | cleric, bard, warlock, wizard | 5e Core Rules |
| Sending | 3rd-level | evocation | bard, cleric, wizard | Level Up Advanced 5e |
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| Shade | 2nd-level | abjuration | bard, cleric, sorcerer, warlock, wizard | Deep Magic 5e |
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| Shadow Armor | 1st-level | abjuration | sorcerer, warlock, wizard | Deep Magic 5e |
| Shadow Bite | Cantrip | illusion | — | Deep Magic 5e |
| Shadow Blindness | Cantrip | illusion | warlock, wizard | Deep Magic 5e |
| Shadow Hands | 1st-level | evocation | warlock, wizard | Deep Magic 5e |
| Shadow Monsters | 4th-level | illusion | sorcerer, warlock, wizard | Deep Magic 5e |
| Shadow Puppets | 2nd-level | illusion | sorcerer, warlock, wizard | Deep Magic 5e |
| Shadow Realm Gateway | 5th-level | conjuration | warlock, wizard | Deep Magic Extended |
| Shadow Spawn | 6th-level | illusion | cleric, wizard | Kobold Press Compilation |
| Shadow Tree | 2nd-level | conjuration | druid, ranger, wizard | Kobold Press Compilation |
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| Shadow's Brand | 2nd-level | necromancy | cleric, ranger, bard, warlock, wizard | Kobold Press Compilation |
| Shadows Brought to Light | 2nd-level | divination | bard, cleric, druid, paladin, warlock, wizard | Deep Magic 5e |
| Shadowy Retribution | 4th-level | necromancy | cleric, sorcerer, warlock, wizard | Deep Magic 5e |
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| Shared Frenzy | 3rd-level | enchantment | bard | Tome of Heroes |
| Shared Sacrifice | 2nd-level | evocation | cleric, paladin | Deep Magic 5e |
| Shatter | 2nd-level | evocation | cleric, bard, sorcerer, warlock, wizard | 5e Core Rules |
| Shatter | 2nd-level | evocation | artificer, bard, sorcerer, warlock, wizard | Level Up Advanced 5e |
| Shattering Barrage | 2nd-level | evocation | bard, cleric, sorcerer, warlock, wizard | Level Up Advanced 5e |