Warp Mind and Matter
Warp Mind and Matter is a 6th-level transmutation available to Bard, Cleric, Druid, Paladin, Ranger, Sorcerer, Warlock, Wizard.

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A creature you can see within range undergoes a baleful transmogrification. The target must make a successful Wisdom saving throw or suffer a flesh warp and be afflicted with a form of indefinite madness.
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Further reading
Jetpack7 Game Master SeriesThe Game Master's Book of Astonishing Random Tables
Ben Egloff · 2023
The Game Master's Book of Random Encounters
Jeff Ashworth · 2020